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The highest coacervate yield (~88%) was obtained with a gum Arabic/chitosan ratio of 5.5:1 and pH of 4.5, when the charge difference between participating polymers was maximal. Viscoelasticity measurement at different biopolymer ratios was performed to determine percent strain and inflection point in the storage and loss moduli and inflection
Coacervate droplets dispersed in a dilute phase. Coacervate (/ k oʊ ə ˈ s ɜːr v ə t / or / k oʊ ˈ æ s ər v eɪ t /) is an aqueous phase rich in macromolecules such as synthetic polymers, proteins or nucleic acids.It forms through liquid-liquid phase separation (LLPS), leading to a dense phase in thermodynamic equilibrium with a dilute phase.The dispersed droplets of dense phase are
Coacervate types Coacervates are divided into simple and complex coacervates, depending on the coacervation mechanism; the former is the self-assembly of macromolecules induced by desolvation or dehydration, and the latter is coacervates formed by electrostatic interactions among macromolecules, such as proteins and polymers ( Astoricchio et al
A coacervate droplet 1 will be engulfed by another coacervate droplet 2 if the total interfacial energy of the resulting multiphase droplet ( Figure 2 d, case 1 in 2) is lower than the combined interfacial energies of the individual droplets: (39) 4π R12 γ 1d + 4π R22 γ 2d > 4π R12 γ 12 + 4π ( R13 + R23) 2/3 γ 2d, which yields. (1) where .
Coacervate Formation and Aggregation of Beta-Amyloid (Aβ) Peptides. (A) A schematic eukaryotic cell showing some of the most relevant membraneless organelles, both inside and outside the nucleus. (B) The pathway that leads to Aβ starts with amyloid precursor protein (APP) internalization through a specialized clathrin-mediated endocytic pathway.
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